Facial Dimensions Linked with Obstructive Sleep Apnea

Thursday, September 2nd, 2010 at 5:23 PM

According to the research findings published in the Journal SLEEP, the researchers hypothesized that the facial phenotype is closely linked to upper airway anatomy.

The aim of this study was to investigate the relationship between surface facial dimensions and upper airway structures using magnetic resonance imaging (MRI) in subjects with obstructive sleep apnea (OSA).

Sixty-nine patients (apnea-hypopnea index ? 10/h) underwent MRI as part of a study of upper airway anatomy in oral appliance therapy in this cohort study.

Measurements of a range of surface facial dimensions and upper airway soft tissue volumes were performed on the MR images using image-analysis software. Pearson correlation analyses were performed.

Significant correlations were identified between a number of surface facial dimensions and neck circumference.

Significant positive correlations were demonstrated between surface facial dimensions (including facial widths, facial heights, nose width, interocular and intercanthal widths) and upper airway structures.

The strongest associations were between the tongue volume and the midface width (r = 0.70, P < 0.001), and lower-face width (r = 0.60, P < 0.001). Surface facial dimensions in combination were also strong determinants for tongue volume (r² = 0.69).

Correlations between surface soft tissue thickness and upper airway soft tissue volumes occurred at the level of the midface but not at the level of the lower face.

This study demonstrates that there is a relationship between surface facial dimensions and upper airway structures in subjects with OSA. These findings support the potential role of surface facial measurements in anatomic phenotyping for OSA.