Obstructive Sleep Apnea Linked With Post-Surgical Delirium
“The association between sleep apnea and postoperative delirium is big news because it may offer us a way to control postoperative delirium which can be devastating,” said senior author Madan Kwatra, Ph.D., a research team member at the Duke University Medical Center.
The study findings will be published in the April 2012 issue of journal Anesthesiology.
Delirium is not a minor consequence. The condition involves an acute and fluctuating consciousness and ability to understand, and is associated with health problems and higher risk of death right after surgery. Delirium is a strong predictor of mortality even 10 years after surgery.
There is hope for prevention, Kwatra said. “If the association between pre-existing sleep apnea and postoperative delirium discovered in this study is confirmed by a larger study, we may be able to prevent postoperative delirium by treating sleep apnea before and immediately after surgery.”
The prospective study investigated patients who were having a total knee replacement, a routine procedure for older patients that restores function and reduces pain.
Out of 106 patients in the study, 27 developed delirium after surgery. Eight out of the 15 patients in the study who had been diagnosed with obstructive sleep apnea experienced post-operative delirium, or 53 percent. By comparison, 20 percent of the patients without sleep apnea (19 out of 91) experienced delirium.
In the analysis, sleep apnea was the only statistically significant factor that predicted delirium out of many medical conditions that were analyzed.
The study provides early evidence that doctors might do better pre-surgical screening for sleep apnea and introduce effective therapy for obstructive sleep apnea as a way to reduce the risk of delirium, Kwatra said.
The causes of postsurgical delirium are still unknown, but lack of oxygen before or after surgery or possibly immune factors that lead to inflammation may play a role, he said.
The study findings support recent recommendations to screen and treat obstructive sleep apnea in an effort to reduce respiratory and cardiovascular problems associated with obstructive sleep apnea.
Tagged with: delirium • Obstructive Sleep Apnea • pain • post operative delirium • post surgical delirium • pre surgical delirium • Sleep Apnea • Sleep Apnea Screening • Surgery • Treating Sleep Apnea
Filed under: Clinical Research • Clinical Trials • Obstructive Sleep Apnea • Polysomnography • Sleep Apnea • Sleep Apnea Diagnosis • Sleep Apnea Effects • Sleep Apnea News • Sleep Apnea Research • Sleep Apnea Surgery • Sleep Apnea Test • Sleep Apnea Treatment • Sleep Disorders
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