Association Between Obstructive Sleep Apnea and Cancer Incidence
Researchers accomplished a detailed investigation whether OSA is associated with increased cancer incidence in a large clinical cohort.
Multicenter, clinical cohort study including consecutive patients investigated for suspected OSA between 2003-2007 in 7 Spanish teaching hospitals. Apnea-hypopnea index (AHI) and percent night-time with oxygen saturation <90% (TSat90) were used as surrogates of OSA severity, both as continuous variables and categorized by tertiles. Cox proportional hazards regression analyses were used to calculate hazard ratios (HR) and 95%CI for cancer incidence after adjusting for confounding variables.
Measurements and main results: 4,910 patients were analyzed (median follow-up 4.5 years, IQR 3.4-5.2). Compared to the lower TSat90 category (<1.2%), the adjusted hazards (95%CI) of cancer incidence for increasing categories were 1.58 (1.07-2.34) for TSat90 1.2%-12% and 2.33 (1.57-3.46) for TSat90>12%. Continuous TSat90 was also associated with cancer incidence (adjusted HR 1.07 [1.02-1.13] per 10-unit increase in TSat90). In stratified analyses, TSat90 was associated with cancer incidence in patients <65 years (adjusted HR 1.13 [95%CI 1.06-1.21] per 10-unit increase in TSat90) and males (adjusted HR 1.11 [95%CI 1.04-1.17] per 10-unit increase in TSat90). AHI was not associated with cancer incidence in the adjusted analyses, except for patients <65 years (adjusted HR for AHI>43 vs. <18.7: 1.66, 95%CI 1.04-2.64).
Increased overnight hypoxia as a surrogate of obstructive sleep apnea severity was associated with increased cancer incidence. This association seems to be limited to men and patients below the age of 65 years.
Like this post? Subscribe to my RSS feed and get loads more!