Clinical Research Archives

Children with sleep disordered breathing (SDB) may have a better  quality of life (QOL) and diminished cardiovascular (CV) disease risk  from the decreased endothelin 1 (ET-1) levels after adenotonsillectomy,  according to new research  published in the journal Otolaryngology–Head and Neck Surgery.

SDB is an increasingly common indication for tonsillectomy and  adenoidectomy due to obstructive sleep apnea (OSA). Cardiovascular  disease frequently has been reported in patients with moderate to severe  OSA. Related abnormalities include: systematic hypertension, pulmonary  hypertension with cor pulmonale, left ventricular hypertrophy or  dysfunction, cardiac arrhythmias, atherosclerosis, and coronary artery  disease. Read the rest of this entry

Sleep disorders often remain undiagnosed. Untreated sleep disorders among police officers may adversely affect their health and safety and pose a risk to the public.

Researchers examined and evaluated associations between sleep disorder risk and self-reported health, safety, and performance outcomes in police officers.

Cross-sectional and prospective cohort study of North American police officers participating in either an online or an on-site screening (n=4957) and monthly follow-up surveys (n=3545 officers representing 15 735 person-months) between July 2005 and December 2007. A total of 3693 officers in the United States and Canada participated in the online screening survey, and 1264 officers from a municipal police department and a state police department participated in the on-site survey.             Read the rest of this entry

For patients with severe obstructive sleep apnea, three months of continuous positive airway pressure (CPAP) therapy is associated with reduced blood pressure, and partial reversal of metabolic abnormalities, according to a study published in the Dec. 15 issue of the New England Journal of Medicine.

Surendra K. Sharma, M.D., Ph.D., from the All India Institute of Medical Sciences in New Delhi, and colleagues investigated the effects of CPAP treatment on metabolic syndrome in 86 patients with obstructive sleep apnea syndrome. Patients were assigned to real or sham CPAP for three months, followed by a washout period of one month, and then a crossover to the other intervention for three months. Anthropometric variables, blood pressure, fasting blood glucose levels and lipid profile, insulin resistance, glycated hemoglobin levels, carotid intima-media thickness, and visceral fat were measured before and after each intervention. Read the rest of this entry

People with obstructive sleep apnea are more likely to stick to prescribed treatment when a partner or parent is involved with their treatment, according to a team of sleep researchers.

Obstructive sleep apnea occurs when the upper airway collapses during sleep. It is the most common type of sleep-disordered breathing, and chances of it occurring become more elevated in obese people.

The first line of treatment for sleep apnea is a non-invasive in-home treatment called CPAP, continuous positive airway pressure therapy. However, if patients do not use the equipment properly, or at all, it cannot help. Read the rest of this entry

New Research To Evaluate Sleep Apnea and Atrial Fibrillation

Case Western Reserve University School of Medicine has received a $3.8 million grant from the National Heart, Lung, and Blood Institute (NHLBI) to study sleep apnea as a possible cause of atrial fibrillation (AF), the most commonly diagnosed type of arrhythmia, or irregular heart rhythm.

AF is characterized by an abnormally rapid heart rate that can inhibit blood flow, and raise the risk of stroke and heart failure. The five-year, NHLBI grant will enable researchers to study how sleep apnea, a treatable disorder in which breathing repeatedly stops and starts during sleep, produces functional and structural changes in the heart that may well contribute to the development of AF. Read the rest of this entry

A recent study by the American Psychiatric Association of Psychiatric  Services concludes a direct connection between sleep apnea and certain  psychiatric conditions. It also points out that the solutions for psychiatric  patients are just as simple as those for all individuals suffering from sleep  apnea. Companies like Rematee provide a solution that is both non-evasive and  ensures side sleeping.

Sleep apnea is a relatively common sleep disorder that causes patients to  stop breathing from 20 seconds to 40 seconds, due to a relaxed and thus  partially collapsed airway. Although it will not outright wake its victims, it  will bring them to a lighter stage of sleep, disrupting the rest and relaxation  needed by the brain, as well as other parts of the body.

Because the brain is so affected by this sleep disorder, much research is  being done as to how it relates to psychiatric conditions.  Studies are showing  that the effects of sleep apnea on certain mental conditions, including that of  Alzheimer’s disease, are actually quite prominent. Read the rest of this entry

The safety and effectiveness of sleep apnea equipment will be examined,evaluated, and determined with the help of a research study conducted by Winston-Salem Company.

Winston-Salem announced that  it has received approval to begin a clinical study to evaluate the  safety and effectiveness of the Apnex hypoglossal Nerve Stimulation (HGNS) System. The device is used to treat obstructive sleep apnea (OSA).

PMG will be one of the first medical centers in the country to participate in this study. “Many people who suffer from OSA are unable to tolerate existing therapies such as continuous positive airway pressure (CPAP). The HGNS System provides a new approach to the treatment of OSA. This study will help us  further understand what role this device could have in treating the millions of people who suffer from OSA,” said the study’s co-principal investigator. Read the rest of this entry

People with diabetes and obstructive sleep apnea are at greater risk of hypoglycemia, a newly concluded research revealed.

People suffering from a sleep disorder who also had poor autonomic function had significantly more hypoglycemia than those with more normal function (P<0.05), Jennifer Cheng, MD, of Rosalind Franklin University of Medicine and Science in Chicago, and colleagues reported here at the World Congress on Insulin Resistance, Diabetes, and Cardiovascular Disease meeting.

“We expected that the symptomatic obstructive sleep apnea patients would have more hyperglycemia, but they actually had more hypoglycemia,” Cheng told MedPage Today. “Clinicians should take into account autonomic function when recommending tight glucose regulation because of the adverse effects that hypoglycemia can cause.” Read the rest of this entry

Sleep apnea screening is rare among psychiatric patients at present, but it’s important to diagnose obstructive sleep apnea (OSA) because it can make mental illness worse, contributing to depression and possibly to the risk of manic episodes.

The symptoms of obstructive sleep apnea can mimic mental illness as well, making patients irritable and tired. If a patient is diagnosed with obstructive sleep apnea it will further complicate the use of benzodiazepines and other respiratory depressants in such patients.

The lead investigator Dr. Vanita Jain, a psychiatry department resident at the University of Utah, Salt Lake City says,” “Sleep problems are so integral to psychiatric problems, [and] we wanted to make sure that along with psychiatric disorders, we were treating obstructive sleep apnea, too”. Read the rest of this entry

University of Chicago scientists have dovered important new relationships between obesity, sleep-disordered breathing (SDB) and cognitive processing among elementary school children.

“The intricate interdependencies between BMI, SDB and cognition shown in our study are of particular importance in children, as their brains are still rapidly developing,” says study author Karen Spruyt, PhD, assistant professor in the Department of Pediatrics at the Pritzer School of Medicine. “Rising rates of obesity in children may amplify these relationships. Public health campaigns targeting obesity should emphasize not only the health benefits but the potential educational benefits of losing weight.”

The findings were published online ahead of print publication in the American Thoracic Society’s American Journal of Respiratory and Critical Care Medicine. Read the rest of this entry

A newly concluded research study findings published online in the European Respiratory Journal, evaluated the impact a Mediterranean diet can have on obese people with sleep apnea, compared to those on a prudent diet.The study revealed that Mediterranean diet combined with physical activity can help to improve some of the symptoms of sleep apnea.

Obstructive sleep apnea syndrome (OSAS) causes frequent pauses of breathing to occur during sleep, which disrupts a person’s normal sleeping pattern. It is one of the most prevalent sleep-related breathing disorders with approximately 2-4% of the adult population experiencing the condition. This percentage increases up to 20-40% with obesity, and weight loss is often an essential part of the recommended treatment plan.

The researchers, from the University of Crete in Greece, examined 40 obese patients suffering from OSAS. Twenty patients were given a prudent diet to follow, while the other 20 followed a Mediterranean diet. Both groups were also encouraged to increase their physical activity, mainly involving walking for at least 30 minutes each day.

In both groups, the patients also received continuous positive airway pressure (CPAP) therapy which involves wearing a mask that generates an air stream, keeping the upper airway open during sleep. Read the rest of this entry

Apnex Medical, Inc., has received CE Mark approval for its Hypoglossal Nerve Stimulation (HGNS®) System for use by people who suffer from obstructive sleep apnea (OSA). The system was approved for sale in Europe based on the positive results of two clinical studies conducted in the United States and Australia. In those studies, the majority of patients demonstrated a significant reduction in their obstructive sleep apnea as well as substantial improvements in the quality of their sleep, quality of life, and overall health.

“CE Mark approval is an important confirmation of the substantial benefits that patients receive from our HGNS therapy for obstructive sleep apnea and is a key milestone for our company,” said Chas McKhann, Apnex Medical President and CEO. Read the rest of this entry

Ventus Medical  revealed the results of a large, long-term study of its proprietary Provent® Sleep Apnea Therapy, an innovative, non-invasive treatment for  obstructive sleep apnea (OSA), were published in the November 2011 issue of the  Journal of Clinical Sleep Medicine, an official publication of the American Academy of Sleep Medicine.

“This study provides further validation that Provent Therapy is an effective  treatment for some OSA patients as it reduces daytime sleepiness, apnea hypopnea  index (AHI) and snoring associated with this prevalent condition,” said Meir  Kryger, M.D., of Gaylord Sleep Medicine and past president of the American  Academy of Sleep Medicine. “Patients reported wearing the device almost 90  percent of the nights, which represents very high compliance. The current gold  standard, continuous positive airway pressure (CPAP) is very effective but many  patients do not use it adequately. Provent represents an important new treatment  option for many obstructive sleep apnea patients.” Read the rest of this entry

Snoring is among the common sleep problems in adults, especially in middle-aged men. And children and kids are equally prone to this most uncomfortable sleep disorder.The effects of snoring upon the overall health of children is established to be detrimental up to great extent.

Association of snoring and obstructive sleep apnea, or OSA among kids and children has now become a more common occurrence. Across the globe occurrence of persistent snoring on most nights has been reported in 8-12 percent of children.

The incidence of OSA (with significant upper airway obstruction leading to   oxygen desaturation and/or sleep fragmentation) is 2-3 percent in children under the age of 10. Read the rest of this entry

Stimulation Therapy For Sleep Apnea Trials

The University Hospitals Case Medical Center is conducting  research study and clinical trials  for evaluating effectiveness of a new implantable device to treat sleep apnea.

The study is aimed to evaluate an electronic device designed to deliver mild stimulation to the main nerve of the tongue — the hypoglossal nerve — on each breathing cycle during sleep.

This stimulation is intended to restore tone to the muscles that control the base of the tongue, which prevent the tongue from collapsing and obstructing the airway during sleep.

Sleep apnea obstruction may not be the only cause for loud snoring but it does affects sleep that is not refreshing. At the same time sleep apnea equally causes daytime sleepiness and a reduced quality of life. Other disorders associated with sleep apnea include development of high blood pressure, as well as cardiovascular diseases, stroke and diabetes. Read the rest of this entry

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